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Pathak Yashwant Antibody-Mediated Drug Delivery Systems. Concepts, Technology, and Applications


This book covers various aspects of antibody mediated drug delivery systems – theoretical aspects, processing, viral and non-viral vectors, and fields where these systems find and /or are being evaluated for applications as therapeutics and diagnostic treatment. Chapters discuss actual applications of techniques used for formulation and characterization. Applications areas include cancer, pulmonary, ocular diseases; brain drug delivery; and vaccine delivery. The contributing authors represent over 10 different countries, covering recent developments happening around the globe.

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Li Chun Drug Delivery Applications of Noninvasive Imaging. Validation from Biodistribution to Sites of Action


Cost-effective strategies for designing novel drug delivery systems that target a broad range of disease conditions In vivo imaging has become an important tool for the development of new drug delivery systems, shedding new light on the pharmacokinetics, biodistribution, bioavailability, local concentration, and clearance of drug substances for the treatment of human disease, most notably cancer. Written by a team of international experts, this book examines the use of quantitative imaging techniques in designing and evaluating novel drug delivery systems and applications. Drug Delivery Applications of Noninvasive Imaging offers a full arsenal of tested and proven methods, practices and guidance, enabling readers to overcome the many challenges in creating successful new drug delivery systems. The book begins with an introduction to molecular imaging. Next, it covers: In vivo imaging techniques and quantitative analysis Imaging drugs and drug carriers at the site of action, including low-molecular weight radiopharmaceuticals, peptides and proteins, siRNA, cells, and nanoparticles Applications of imaging techniques in administration routes other than intravenous injection, such as pulmonary and oral delivery Translational research leading to clinical applications Imaging drug delivery in large animal models Clinical applications of imaging techniques to guide drug development and drug delivery Chapters are based on a thorough review of the current literature as well as the authors' firsthand experience working with imaging techniques for the development of novel drug delivery systems. Presenting state-of-the-technology applications of imaging in preclinical and clinical evaluation of drug delivery systems, Drug Delivery Applications of Noninvasive Imaging offers cost-effective strategies to pharmaceutical researchers and students for developing drug delivery systems that accurately target a broad range of disease conditions.

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Nokhodchi Ali Pulmonary Drug Delivery. Advances and Challenges


Drug therapy via inhalation route is at the cutting edge of modern drug delivery research. There has been significant progress on the understanding of drug therapy via inhalation products. However, there are still problems associated with their formulation design, including the interaction between the active pharmaceutical ingredient(s) (APIs), excipients and devices. This book seeks to cover some of the most pertinent issues and challenges of such formulation design associated with industrial production and desirable clinical outcome. The chapter topics have been selected with a view to integrating the factors that require consideration in the selection and design of device and formulation components which impact upon patient usability and clinical effectiveness. The challenges involved with the delivery of macromolecules by inhalation to both adult and pediatric patients are also covered. Written by leading international experts from both academia and industry, the book will help readers (formulation design scientists, researchers and post-graduate and specialized undergraduate students) develop a deep understanding of key aspects of inhalation formulations as well as detail ongoing challenges and advances associated with their development.

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Rebecca A. Bader Engineering Polymer Systems for Improved Drug Delivery


Polymers have played a critical role in the rational design and application of drug delivery systems that increase the efficacy and reduce the toxicity of new and conventional therapeutics. Beginning with an introduction to the fundamentals of drug delivery, Engineering Polymer Systems for Improved Drug Delivery explores traditional drug delivery techniques as well as emerging advanced drug delivery techniques. By reviewing many types of polymeric drug delivery systems, and including key points, worked examples and homework problems, this book will serve as a guide to for specialists and non-specialists as well as a graduate level text for drug delivery courses.

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Группа авторов Computational Pharmaceutics


Molecular modeling techniques have been widely used in drug discovery fields for rational drug design and compound screening. Now these techniques are used to model or mimic the behavior of molecules, and help us study formulation at the molecular level. Computational pharmaceutics enables us to understand the mechanism of drug delivery, and to develop new drug delivery systems. The book discusses the modeling of different drug delivery systems, including cyclodextrins, solid dispersions, polymorphism prediction, dendrimer-based delivery systems, surfactant-based micelle, polymeric drug delivery systems, liposome, protein/peptide formulations, non-viral gene delivery systems, drug-protein binding, silica nanoparticles, carbon nanotube-based drug delivery systems, diamond nanoparticles and layered double hydroxides (LDHs) drug delivery systems. Although there are a number of existing books about rational drug design with molecular modeling techniques, these techniques still look mysterious and daunting for pharmaceutical scientists. This book fills the gap between pharmaceutics and molecular modeling, and presents a systematic and overall introduction to computational pharmaceutics. It covers all introductory, advanced and specialist levels. It provides a totally different perspective to pharmaceutical scientists, and will greatly facilitate the development of pharmaceutics. It also helps computational chemists to look for the important questions in the drug delivery field. This book is included in the Advances in Pharmaceutical Technology book series.

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Pet Feeding Drug Stick Cat Eating Medicine Water Dropper Device Drug Delivery Pet Feeding Device Feeder

Группа авторов Nanoparticulate Drug Delivery Systems


Frank discussions of opportunities and challenges point the way to new, more effective drug delivery systems Interest in nanomedicine has grown tremendously, fueled by the expectation that continued research will lead to the safe, efficient, and cost-effective delivery of drugs or imaging agents to human tissues and organs. The field, however, has faced several challenges attempting to translate novel ideas into clinical benefits. With contributions from an international team of leading nanomedicine researchers, this book provides a practical assessment of the possibilities and the challenges of modern nanomedicine that will enable the development of clinically effective nanoparticulate drug delivery products and systems. Nanoparticulate Drug Delivery Systems focuses on the rationales and preclinical evaluation of new nanoparticulate drug carriers that have yet to be thoroughly reviewed in the literature. The first chapter sets the stage with a general overview of targeted nanomedicine. The book then explores new and promising nanoparticulate drug delivery systems, including: Lipid nanoparticles for the delivery of nucleic acids Multifunctional dendritic nanocarriers Polymer drug nanoconjugates Next, the book presents new opportunities and challenges for nanoparticulate drug delivery systems, including: Clearance of nanoparticles during circulation Drug delivery strategies for combatting multiple drug resistance Toxicological assessment of nanomedicine Chapters offer state-of-the-technology reviews with extensive references to facilitate further investigation. Moreover, each chapter concludes with an expert assessment of remaining challenges, pointing the way to solutions and new avenues of research. With its frank discussions of opportunities and challenges, Nanoparticulate Drug Delivery Systems sets a solid foundation for new research leading to the discovery and development of better nanomedicines.

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Dionysios Douroumis Drug Delivery Strategies for Poorly Water-Soluble Drugs


Many newly proposed drugs suffer from poor water solubility, thus presenting major hurdles in the design of suitable formulations for administration to patients. Consequently, the development of techniques and materials to overcome these hurdles is a major area of research in pharmaceutical companies. Drug Delivery Strategies for Poorly Water-Soluble Drugs provides a comprehensive overview of currently used formulation strategies for hydrophobic drugs, including liposome formulation, cyclodextrin drug carriers, solid lipid nanoparticles, polymeric drug encapsulation delivery systems, self–microemulsifying drug delivery systems, nanocrystals, hydrosol colloidal dispersions, microemulsions, solid dispersions, cosolvent use, dendrimers, polymer- drug conjugates, polymeric micelles, and mesoporous silica nanoparticles. For each approach the book discusses the main instrumentation, operation principles and theoretical background, with a focus on critical formulation features and clinical studies. Finally, the book includes some recent and novel applications, scale-up considerations and regulatory issues. Drug Delivery Strategies for Poorly Water-Soluble Drugs is an essential multidisciplinary guide to this important area of drug formulation for researchers in industry and academia working in drug delivery, polymers and biomaterials.

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Группа авторов Bioadhesives in Drug Delivery

Группа авторов Chemical Aspects of Drug Delivery Systems

Pulmonary Drug Delivery von Ali Nokhodchi | ISBN 978-1-118 ...

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Pulmonary Drug Delivery: Advances and Challenges Ali Nokhodchi, Gary P. Martin Drug therapy via inhalation route is at the cutting edge of modern drug delivery research. There has been significant progress on the understanding of drug therapy via inhalation products. However, there are still problems associated with their formulation design, including the interaction between the active ...

‪Ali Nokhodchi, Professor of Pharmaceutics and Drug ...

Ali Nokhodchi, Professor of Pharmaceutics and Drug Delivery. University of Sussex. Verified email at sussex.ac.uk. Particle engineering (micro/nano) Pulmonary drug Delivery Novel Drug Delivery Systems Solid dosage form formulations Transde. Articles Cited by. Title. Sort. Sort by citations Sort by year Sort by title. Cited by. Cited by . Year; The effect of type and concentration of vehicles ...

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Pulmonary drug delivery: advances and challenges. Nokhodchi, Ali, editor; Martin, Gary P., 1954- editor. Drug therapy via inhalation route is at the cutting edge of modern drug delivery research. There has been significant progress on the understanding of drug therapy via inhalation products. However, there are still problems associated with their formulation design, including the interaction ...

Nokhodchi Lab : School of Life Sciences : University of Sussex

He completed his PhD on Pharmaceutical Technology at John Moores University, Liverpool in 1996 and has been a qualified pharmacist since 1989.He held a lectureship (1997 - 2001), and senior lectureship (2001 - 2003) at the School of Pharmacy, Tabriz University of Medical Sciences.

Items for Nokhodchi, Ali : Sussex Research Online

Kaialy, Waseem and Nokhodchi, Ali (2013) Freeze-dried mannitol for superior pulmonary drug delivery via dry powder inhaler. Pharmaceutical Research, 30 (2). pp. 458-477. ISSN 0724-8741

Ali NOKHODCHI | Professor of Pharmaceutics and Drug ...

Ali NOKHODCHI, Professor of Pharmaceutics and Drug Delivery of University of Sussex, Brighton | Read 349 publications | Contact Ali NOKHODCHI

Dr Ali Nokhodchi - Drug Applied Research Center

Dr Ali Nokhodchi: Head of Pharmaceutical Technology Laboratory Associate professor and head of postgraduate studies . Tel: 0098 41 33363311. Fax: 0098 41 33363231 . E-mail: [email protected] Dr Nokhodchi's Home Page Curriculum Vitae: Dr Ali Nokhodchi is associate professor of Pharmaceutical Technology and head of postgraduate studies in school of Pharmacy in Tabriz University of Medical ...

Publications : Nokhodchi Lab : School of Life Sciences ...

Kaialy, Waseem and Nokhodchi, Ali (2013) Freeze-dried mannitol for superior pulmonary drug delivery via dry powder inhaler. Pharmaceutical Research, 30 (2). pp. 458-477. ISSN 0724-8741

Ali Nokhodchi - Professor in Pharmaceutics and Drug ...

Ali Nokhodchi has published over 240 research articles in the fields of particle engineering, solid dosage forms, nanomedicines, pulmonary, transdermal and oral delivery (updated on 1st February...

Pulmonary Drug Delivery | Wiley Online Books

ALI NOKHODCHI School of Life Sciences, University of Sussex, UK GARY P. MARTIN Institute of Pharmaceutical Science, King’s College London, UK

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Nokhodchi Ali. Pulmonary Drug Delivery. Advances and Challenges. Pulmonary Drug Delivery. Advances and Challenges. Автор . Nokhodchi Ali Год написания книги. 2018. Drug therapy via inhalation route is at the cutting edge of modern drug delivery research. There has been significant progress on the understanding of drug therapy via inhalation products. However, there are ...

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Ali Nokhodchi & Gary P. Martin Pulmonary Drug Delivery Advances and Challenges. Support. Adobe DRM (4.3 / 5.0 – 2 customer ratings) Drug therapy via inhalation route is at the cutting edge of modern drug delivery research. There has been significant progress on the understanding of drug therapy via inhalation products. However, there are still problems associated with their formulation ...

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Ali Nokhodchi & Gary P. Martin Pulmonary Drug Delivery Advances and Challenges. Support. Adobe DRM (4.1 / 5.0 – 2 customer ratings) Drug therapy via inhalation route is at the cutting edge of modern drug delivery research. There has been significant progress on the understanding of drug therapy via inhalation products. However, there are still problems associated with their formulation ...

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Titre(s) : Pulmonary drug delivery [Texte électronique] : advances and challenges / edited by Ali Nokhodchi and Gary P. Martin. Publication : Chichester, United Kingdom ; Hoboken, NJ : Wiley, 2015. Description matérielle : 1 online resource. Collection : Advances in pharmaceutical technology. Note(s) : Includes bibliographical references and index. - Print version record and CIP data ...

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Carriers for Pulmonary Drug Delivery A State of the Art Review 123 Yahya Rahimpour, Hamed Hamishehkar, and Ali Nokhodchi 6.1 Introduction 124 6.2 Pulmonary Drug Delivery 125 6.3 Liposomal Pulmonary Delivery 126 6.4 Nebulization of Liposomes 126 6.5 Liposomal Dry

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Yahya Rahimpour, Hamed Hamishehkar, and Ali Nokhodchi. 6.1 Introduction 124. 6.2 Pulmonary Drug Delivery 125. 6.3 Liposomal Pulmonary Delivery 126. 6.4 Nebulization of Liposomes 126. 6.5 Liposomal Dry-powder Inhalers 128. 6.6 Solid Lipid Microparticles in Pulmonary Drug Delivery 129. 6.7 Solid Lipid Nanoparticles in Pulmonary Drug Delivery 131

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Pulmonary drug delivery : advances and challenges / edited by Ali Nokhodchi and Gary P. Martin. Format Book; Language English; Published/ Created. Chichester, West Sussex, [England] : Wiley, 2015. ©2015 ; Description 1 online resource (505 pages). Details Subject(s) Drug delivery systems; Pulmonary pharmacology; Editor. Nokhodchi, Ali; Martin, Gary P., 1954-Series. Advances in pharmaceutical ...

Pulmonary Drug Delivery: Advances and Challenges / Edition ...

Yahya Rahimpour, Hamed Hamishehkar, and Ali Nokhodchi. 6.1 Introduction 124. 6.2 Pulmonary Drug Delivery 125. 6.3 Liposomal Pulmonary Delivery 126. 6.4 Nebulization of Liposomes 126. 6.5 Liposomal Dry-powder Inhalers 128. 6.6 Solid Lipid Microparticles in Pulmonary Drug Delivery 129. 6.7 Solid Lipid Nanoparticles in Pulmonary Drug Delivery 131

Tomalia Donald A. Dendrimer-Based Drug Delivery Systems. From Theory to Practice


The opportunities and challenges of using dendrimers to improve drug delivery Among pharmaceutical and biomedical researchers, the use of dendrimers in drug delivery systems has attracted increasing interest. In particular, researchers have noted that the volume of a dendrimer increases when it has a positive charge. If this property can be applied effectively, dendrimers have enormous potential in drug delivery systems, directly supplying medication to targeted human organs. With contributions from an international team of pioneers and experts in dendrimer research, this book provides a comprehensive overview of the latest research efforts in designing and optimizing dendrimer-based drug delivery systems. The book analyzes key issues, demonstrating the critical connections that link fundamental concepts, design, synthesis, analytical methodology, and biological assessment to the practical use of dendrimers in drug delivery applications. Topics covered include: Dendrimer history Synthesis Physicochemical properties Principles of drug delivery Applications in diverse biomedical fields Dendrimer-Based Drug Delivery Systems reflects the authors' thorough review and analysis of the current literature as well as their own firsthand experience in the lab. Readers will not only discover the current state of the science, but also gain valuable insights into fruitful directions for future research. References at the end of each chapter serve as a gateway to the growing body of literature in the field, enabling readers to explore each individual topic in greater depth. Pharmaceutical and biomedical researchers will find this book a unique and essential guide to the opportunities, issues, and challenges involved in fully exploiting the potential of dendrimers to improve drug delivery.

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Laurent Simon Control of Biological and Drug-Delivery Systems for Chemical, Biomedical, and Pharmaceutical Engineering


Enables readers to apply process dynamics and control theory to solve bioprocess and drug delivery problems The control of biological and drug delivery systems is critical to the health of millions of people worldwide. As a result, researchers in systems biology and drug delivery rely on process dynamics and control theory to build our knowledge of cell behavior and to develop more effective therapeutics, controlled release devices, and drug administration protocols to manage disease. Written by a leading expert and educator in the field, this text helps readers develop a deep understanding of process dynamics and control theory in order to analyze and solve a broad range of problems in bioprocess and drug delivery systems. For example, readers will learn how stability criteria can be used to gain new insights into the regulation of biological pathways and lung mechanics. They'll also learn how the concept of a time constant is used to capture the dynamics of diffusive processes. Readers will also master such topics as external disturbances, transfer functions, and input/output models with the support of the author's clear explanations, as well as: Detailed examples from the biological sciences and novel drug delivery technologies 160 end-of-chapter problems with step-by-step solutions Demonstrations of how computational software such as MATLAB and Mathematica solve complex drug delivery problems Control of Biological and Drug-Delivery Systems for Chemical, Biomedical, and Pharmaceutical Engineering is written primarily for undergraduate chemical and biomedical engineering students; however, it is also recommended for students and researchers in pharmaceutical engineering, process control, and systems biology. All readers will gain a new perspective on process dynamics and control theory that will enable them to develop new and better technologies and therapeutics to treat human disease.

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Nahar Chowdhury Lutfun Steroid Dimers. Chemistry and Applications in Drug Design and Delivery


Steroid dimers are an important group of compounds produced by various marine organisms, and also synthesized in the laboratories. This group of compounds possesses various pharmacological and biological properties, and can also be used to create “molecular umbrellas” for drug delivery. Steroid Dimers: Chemistry and Applications in Drug Design and Delivery provides an up-to-date overview on the chemistry and applications of steroid dimers of natural and synthetic origins. The book includes easy-to-follow synthetic protocols for various classes of important dimeric steroids, source details, valuable spectroscopic data and depiction of unique structural features of natural steroidal dimers, and the Structure-Activity-Relationships (SARs) of some pharmacologically active dimeric steroids. Topics covered include: introduction to steroid dimers synthesis and chemistry of noncyclic and cyclic steroid dimers naturally occurring steroid dimers – cephalostatins, ritterazines and crellastatins biological and pharmacological functions of steroid dimers and their application in drug design and discovery steroid dimers as “molecular umbrellas” for drug delivery Steroid Dimers: Chemistry and Applications in Drug Design and Delivery is an essential guide to this important class of natural and synthetic compounds for researchers and students of natural products chemistry and biochemistry, synthetic organic and medicinal chemistry, and drug design, discovery and delivery.

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Rossi John J. RNA Interference. Application to Drug Discovery and Challenges to Pharmaceutical Development


RNA Interference: Application to Drug Discovery and Challenges to Pharmaceutical Development provides a general overview of this rapidly emerging field, with a strong emphasis on issues and aspects that are important to a drug development team. The first part covers more general background of RNA interference and its application in drug discovery. In the second part, the book addresses siRNA (small interfering RNA), a pharmaceutically potent form, and its use and delivery in therapeutics along with manufacturing and delivery aspects.

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Michael R Hamblin Advances in Nanomaterials for Drug Delivery


Nanomedicine is a developing field, which includes different disciplines such as material science, chemistry, engineering and medicine devoted to the design, synthesis and construction of high-tech nanostructures. The ability of these structures to have their chemical and physical properties tuned by structural modification, has allowed their use in drug delivery systems, gene therapy delivery, and various types of theranostic approaches. Colloidal noble metal nanoparticles and other nanostructures have many therapeutic and diagnostic applications. The concept of drug targeting as a magic bullet has led to much research in chemical modification to design and optimize the binding to targeted receptors. It is important to understand the precise relationship between the drug and the carrier and its ability to target specific tissues, and pathogens to make an efficient drug delivery system. This book covers advances based on different drug delivery systems: polymeric and hyper branched nanomaterials, carbon-based nanomaterials, nature-inspired nanomaterials, and pathogen-based carriers.

2421.29 RUR

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Navid Rabiee Nanoparticle (NP)-Based Delivery Vehicles


Gene therapy as a potential method for treatment of genetic disorders and other malignancies as well as treatment of many cancers has attracted a great amount of attention in recent years. Current research focuses on stable and smart drug/gene delivery systems, including controlled release. Smart nanostructures have been considered as a promising approach when applied to drug and gene delivery systems, and could solve the problems related to the inefficient transfer of medication to the affected cells.

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Группа авторов Novel Delivery Systems for Transdermal and Intradermal Drug Delivery


This research book covers the major aspects relating to the use of novel delivery systems in enhancing both transdermal and intradermal drug delivery. It provides a review of transdermal and intradermal drug delivery, including the history of the field and the various methods employed to produce delivery systems from different materials such as device design, construction and evaluation, so as to provide a sound background to the use of novel systems in enhanced delivery applications. Furthermore, it presents in-depth analyses of recent developments in this exponentially growing field, with a focus on microneedle arrays, needle-free injections, nanoparticulate systems and peptide-carrier-type systems. It also covers conventional physical enhancement strategies, such as tape-stripping, sonophoresis, iontophoresis, electroporation and thermal/suction/laser ablation Discussions about the penetration of the stratum corneum by the various novel strategies highlight the importance of the application method. Comprehensive and critical reviews of transdermal and intradermal delivery research using such systems focus on the outcomes of in vivoanimal and human studies. The book includes laboratory, clinical and commercial case studies featuring safety and patient acceptability studies carried out to date, and depicts a growing area for use of these novel systems is in intradermal vaccine delivery. The final chapters review recent patents in this field and describe the work ongoing in industry.

12038.52 RUR

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Buchwald Peter Retrometabolic Drug Design and Targeting


Innovative approach to drug design that's more likely to result in an approvable drug product Retrometabolic drug design incorporates two distinct drug design approaches to obtain soft drugs and chemical delivery systems, respectively. Combining fundamentals with practical step-by-step examples, Retrometabolic Drug Design and Targeting gives readers the tools they need to take full advantage of retrometabolic approaches in order to develop safe and effective targeted drug therapies. The authors, both pioneers in the fields of soft drugs and retrometabolic drug design, offer valuable ideas, approaches, and solutions to a broad range of challenges in drug design, optimization, stability, side effects, and toxicity. Retrometabolic Drug Design and Targeting begins with an introductory chapter that explores new drugs and medical progress as well as the challenges of today's drug discovery. Next, it discusses: Basic concepts of the mechanisms of drug action Drug discovery and development processes Retrometabolic drug design Soft drugs Chemical delivery systems Inside the book, readers will find examples from different pharmacological areas detailing the rationale for each drug design. These examples set forth the relevant pharmacokinetic and pharmacodynamic properties of the new therapeutic agents, comparing these properties to those of other compounds used for the same therapeutic purpose. In addition, the authors review dedicated computer programs that are available to support and streamline retrometabolic drug design efforts. Retrometabolic Drug Design and Targeting is recommended for all drug researchers interested in employing this newly tested and proven approach to developing safe and effective drugs.

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Ryan Donnelly F. Microneedles for Drug and Vaccine Delivery and Patient Monitoring


Provides comprehensive coverage of microneedles for delivering and monitoring patient drugs and vaccines Microneedles are an incredibly active research area and have the potential to revolutionize the way many medicines and vaccines are delivered. This comprehensive research book covers the major aspects relating to the use of microneedle arrays in enhancing both transdermal and intradermal drug delivery and provides a sound background to the use of microneedle arrays in enhanced delivery applications. Beginning with a history of the field and the various methods employed to produce microneedles from different materials, Microneedles for Drug and Vaccine Delivery and Patient Monitoring discusses the penetration of the stratum corneum by microneedles and the importance of application method and force and microneedle geometry (height, shape, inter-needle spacing). Transdermal and intradermal delivery research using microneedles is comprehensively and critically reviewed, focusing on the outcomes of in vivo animal and human studies. The book describes the important topics of safety and patient acceptability studies carried out to date. It also covers in detail the growing area for microneedle use in the monitoring of interstitial fluid contents. Finally, it reviews translational and regulatory developments in the microneedles field and describes the work ongoing in industry. The only book currently available on microneedles Filled with tables, graphs, and black and white images (photographs, micrographs) Authored by four experts in pharmaceutics Microneedles for Drug and Vaccine Delivery and Patient Monitoring is an ideal source for researchers in industry and academia working on drug delivery and transdermal delivery in particular, as well as for advanced students in pharmacy and pharmaceutical sciences.

15466.18 RUR

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Matthijs Oudkerk Deep Vein Thrombosis and Pulmonary Embolism


Dedicated to dealing with a challenging disease, previously thought to be incurable, but with the advent of new drugs, now amenable to management and a much improved prognosis for patients. – Latest publication in a fast-moving area of keen clinical interest – Authored by leading international authorities – Builds on success of a respected first edition – Incorporates new data on latest imaging technologies and therapies – Covers both the science and clinical aspects, including presentation, surgical intervention and drug therapy – Includes coverage of both Pulmonary Embolism and Deep Vein Thrombosis

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